文章摘要
针刺结合医用臭氧注射在膝骨性关节炎治疗作用中的系统评价
Systematic evaluation of acupuncture combined with medical ozone injection in the treatment of knee osteoarthritis
投稿时间:2019-06-03  录用日期:2019-07-01
DOI:
中文关键词: 针刺  臭氧  膝骨性关节炎  系统评价
英文关键词: acupuncture  ozone  knee osteoarthritis  
基金项目:国家自然科学基金项目(面上项目,重点项目,重大项目)
作者单位E-mail
王成龙 辽宁中医药大学 1007824404@qq.com 
董宝强 辽宁中医药大学 peterbaoqiang@163.com 
曲超 辽宁中医药大学  
林星星 辽宁中医药大学  
王刚 北方战区总医院北陵分院  
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中文摘要:
      目的:系统评价针刺结合医用臭氧注射治疗膝骨性关节炎的临床疗效和安全性。方法:依据荟萃分析要求,全面检索CBM、CNKI、VIP、PubMed、Embase及TheCochraneLibrary等数据库,纳入以针刺结合医用臭氧注射为干预措施治疗膝骨性关节炎且为随机对照试验或临床对照试验的研究文献,文献的检索年限均为建库至2019年4月。由两名经过培训的研究人员独立进行检索并提取资料,如果遇到分歧,找第三方(老师或者专家)协助解决。采用Cochrane协作网提供的ReviewManager5.3软件进行数据的荟萃分析。结果:最终纳入15篇RCT或CCT,受试者共1244例,10篇文献报道总有效率,总有效率异质性检验:[Chi2=5.07,P=0.83,I2=0%,OR=4.00,95%CI(2.72,5.89),Z=7.03,P<0.00001]。10篇文献报道了VAS评分,异质性检验,[MD=-1.72,95%CI(-2.39,-1.06),Z=5.10,(P<0.00001)]。2篇文献报道了WOMAC指数,异质性检验,[Chi2=0.01,P=0.91,I2=0%,MD=-6.84,95%CI(-9.23,-4.45),Z=5.61,P<0.00001]。2篇文献报道了Lysholm膝关节功能评分,异质性检验,[Chi2=0.84,P=0.36,I2=0%,MD=7.97,95%CI(5.60,10.34),Z=6.60,P<0.00001]。仅有1篇文献报道不良反应的发生。结论:针刺结合医用臭氧注射治疗膝骨性关节炎疗效显著,易于推广,但其结论的验证今后还需要大样本高质量临床试验进一步验证。
英文摘要:
      Objective: To systematically evaluate the clinical efficacy and safety of acupuncture combined with medical ozone injection in the treatment of knee osteoarthritis. Methods: According to the meta-analysis requirements, a comprehensive search of CBM, CNKI, VIP, PubMed, Embase and TheCochraneLibrary database, including acupuncture combined with medical ozone injection as an intervention to treat knee osteoarthritis and randomized controlled trials or clinical controlled trials In the research literature, the search period of the literature was built until April 2019. Two trained researchers independently search and extract information. If there is a disagreement, seek a third party (teacher or expert) to help solve the problem. A meta-analysis of the data was performed using ReviewManager 5.3 software provided by the Cochrane Collaboration. RESULTS: A total of 15 RCTs or CCTs were included, and a total of 1244 subjects were reported. Ten articles reported total effective rate and total efficiency heterogeneity test: [Chi2=5.07, P=0.83, I2=0%, OR=4.00 , 95% CI (2.72, 5.89), Z = 7.03, P < 0.00001]. Ten papers reported VAS scores, heterogeneity tests, [MD = -1.72, 95% CI (-2.39, -1.06), Z = 5.10, (P < 0.00001)]. Two papers reported the WOMAC index, heterogeneity test, [Chi2=0.01, P=0.91, I2=0%, MD=-6.84, 95% CI (-9.23,-4.45), Z=5.61, P<0.00001 ]. Two literatures reported Lysholm knee function score, heterogeneity test, [Chi2=0.84, P=0.36, I2=0%, MD=7.97, 95% CI (5.60, 10.34), Z=6.60, P<0.00001 ]. Only one document reported the occurrence of adverse reactions. Conclusion: Acupuncture combined with medical ozone injection is effective in the treatment of knee osteoarthritis, and it is easy to promote it. However, the verification of its conclusion needs further verification of large-scale high-quality clinical trials in the future.
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