化瘀通络灸对VD患者认知功能及外周血BDNF、VEGF水平的影响

姚婷婷; 张庆萍

文章摘要

化瘀通络灸对VD患者认知功能及外周血BDNF、VEGF水平的影响

Effect of Huayu Tongluo moxibustion on Cognitive function and Peripheral Blood BDNF、VEGF level in patients with VD

投稿时间：2019-06-06 录用日期：2019-08-15

DOI：

中文关键词: 血管性痴呆化瘀通络灸认知功能血管内皮生长因子脑源性神经营养因子

英文关键词: Vascular dementia Huayu Tongluo moxibustion Cognitive function Vascular Endothelial growth Factor brain-derived Neurotrophic Factor

基金项目:国家自然科学基金项目（面上项目，重点项目，重大项目）

作者	单位	邮编
姚婷婷	安徽中医药大学	230000
张庆萍^*	安徽中医药大学	230000

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中文摘要:

目的：通过化瘀通络灸对血管性痴呆(Vascular dementia,VD)患者的临床干预,观察其对认知功能的影响并探讨其对脑源性神经营养因子(Brain Derived Neurotrophic Factor,BDNF)、血管内皮生长因子(Vascular Endothelial Growth Factor,VEGF)的影响。方法：按随机数字表法将30例VD患者随机分为化瘀通络灸组15例和西药组15例。化瘀通络灸组予艾灸治疗,3次/周；西药组予盐酸多奈哌齐口服,5mg/晚,同时两组均口服尼莫地平为基础治疗,30mg,3次/日；两组均治疗12周。观察2组治疗前后MMSE、ADL量表积分及血清BDNF、VEGF水平的变化。结果：化瘀通络灸组,治疗后MMSE、ADL量表评分、血清BDNF、VEGF水平均较治疗前显著升高(P＜0.05)；且治疗后各量表积分及血清BDNF、VEGF水平与西药组比较均显著增高(P＜0.01)。疗效统计：化瘀通络灸组总有效率93.30％,纯西药组总有效率53.33％,两组疗效比较,差异有统计学意义(P＜0.05)。结论：化瘀通络灸是一种有效的治疗方法,可能通过增加VEGF、BDNF的表达,保护受损的血管及神经元,促进形成新的神经元,从而改善VD患者认知功能及日常生活能力,为临床中VD的诊断治疗提供参考依据。

英文摘要:

objective: to observe the effect of Huayu Tongluo moxibustion on cognitive function in patients with vascular dementia (Vascular dementia,VD) and to explore its effect on brain-derived neurotrophic factor (Brain Derived Neurotrophic Factor,BDNF). Effect of vascular endothelial growth factor (Vascular Endothelial Growth Factor,VEGF). Methods: according to the method of random digital table, 30 patients with VD were randomly divided into Huayu Tongluo moxibustion group 1. There were 5 cases in the western medicine group and 15 cases in the western medicine group. Huayu Tongluo moxibustion group was treated with moxibustion for 3 times a week, and the western medicine group was treated with donepezil hydrochloric acid, 5mg/ late, and both groups were treated with nimodipine for 30 mg, 3 times a day, and both groups were treated for 12 weeks. The changes of MMSE,ADL scale score and serum BDNF,VEGF level were observed before and after treatment. Results: in Huayu Tongluo moxibustion group, the score of MMSE,ADL scale and the level of serum BDNF,VEGF after treatment were significantly higher than those before treatment, and the scores of each scale and the level of serum BDNF,VEGF after treatment were significantly higher than those before treatment. Compared with pure western medicine group, it was significantly higher than that in pure western medicine group (P < 0.05). The total effective rate was 93.30% in Huayu Tongluo moxibustion group and 53.33% in pure western medicine group. There was significant difference between the two groups (P < 0.01). Conclusion: Huayu Tongluo moxibustion is an effective treatment, which may improve the cognitive function and daily living ability of patients with VD by increasing the expression of VEGF,BDNF, protecting the damaged blood vessels and neurons, and promoting the formation of new neurons. It provides a reference for the diagnosis and treatment of VD in clinic.

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