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| 超微针刀结合加巴喷丁治疗带状疱疹后遗神经痛的临床观察 |
| Clinical observation on the treatment of postherpetic neuralgia with ultramicro needle knife and gabapentin |
| 投稿时间：2019-12-05 录用日期：2020-01-03 |
| DOI： |
| 中文关键词: 带状疱疹后遗神经痛 超微针刀 |
| 英文关键词: postherpetic neuralgia ultramicro needle knife |
| 基金项目:湖南省自然科学青年基金 |
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| 摘要点击次数: 39 |
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| 中文摘要: |
| 目的：通过观察和评价超微针刀结合加巴喷丁对带状疱疹后遗神经痛的治疗效果，并与单纯服用加巴喷丁药物治疗进行比较，寻求一种针对带状疱疹后遗神经痛更加安全有效的治疗方法。方法：将62例带状疱疹后遗神经痛患者随机分成观察组和对照组，每组31例。观察组运用超微针刀结合加巴喷丁进行治疗，超微针刀隔日1次，每周3次。加巴喷丁每日服用。按以上疗法连续治疗4周。对照组运用口服加巴喷丁进行治疗，每日3次，连续治疗4周。采用整体临床疗效、VAS疼痛评分、焦虑自评量表 (SAS)评分、Th1/Th2细胞因子与血清炎症因子水平，对治疗前后的情况进行比较以判定。结果：1.整体临床疗效比较:观察组优于对照组（p＜0.05）；2.观察组在治疗第2、4周后的VAS评分均显著低于对照组（均P＜0.01）；3.观察组在治疗第2、4周后的SAS评分均显著低于对照组（均P＜0.01）。两组治疗后比较IL－1β水平较治疗前均降低，但无统计学意义（P＞0.05）；两组治疗后IL－2水平均较治疗前上升，差异有统计学意义（P＜0.05），且观察组治疗结束后IL-2值高于对照组，说明两组均能提高IL-2值，且观察组提高IL-2值幅度大于对照组，差异有统计学意义（P＜0.05）。结论：超微针刀结合加巴喷丁治疗能明显减轻带状疱疹后遗神经痛患者的疼痛，改善此类患者的焦虑抑郁状态，提高IL-2值，较单纯服用加巴喷丁临床疗效更佳。 |
| 英文摘要: |
| Objective: To observe and evaluate the therapeutic effect of ultra fine needle scalpel combined with gabapentin on postherpetic neuralgia, and to find a more safe and effective treatment for postherpetic neuralgia. Methods: 62 patients with postherpetic neuralgia were randomly divided into observation group and control group, 31 cases in each group. The observation group was treated with ultramicro needle knife and gabapentin once every other day, three times a week. Gabapentin is taken daily. According to the above treatment for 4 weeks. The control group was treated with oral gabapentin three times a day for four weeks. The clinical effect, VAS pain score, SAS score, Th1 / Th2 cytokines and serum inflammatory factors were compared before and after treatment. Results: 1. Overall clinical efficacy comparison: the observation group was better than the control group (P < 0.05); 2. The VAS score of the observation group was significantly lower than that of the control group (P < 0.01); 3. The SAS score of the observation group was significantly lower than that of the control group (P < 0.01). After treatment, the level of IL-1 β in the two groups was lower than that before treatment, but there was no statistical significance (P > 0.05); after treatment, the level of IL-2 in the two groups was higher than that before treatment, the difference was statistically significant（P＜0.05）. Conclusion: the combination of ultramicro needle scalpel and gabapentin can significantly reduce the pain of patients with postherpetic neuralgia, improve the state of anxiety and depression of such patients, and improve the value of IL-2, which is better than the clinical effect of gabapentin alone. |
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